The charges relate to the alleged exploitation of five teenagers between May and September last year.
Brothers Gulfraz Banaris, 20, Ifaraz Banaris, 25, from Deedmore Road, Wood End, Coventry, and Izthkhab Banaris, 24, from Eld Road, Coventry, are charged with conspiracy to traffic girls across the city for the purposes of sexual exploitation. Gulfraz and Izthkhab are also both accused of a rape.
A police spokesman said all three men appeared before magistrates in Coventry on Thursday and were remanded in custody to face Coventry Crown Court on November 7.
Brothers Isa Iqbal, 21, Ismail Iqbal, 20, both of no fixed address and cousins of the Banaris brothers, also face trafficking counts and are due to reappear in court in November.
Meanwhile, five other men are due to appear in court in Coventry on Friday in connection with the inquiry.
Ricardo Hinkson, 23, from Telfer Road, Radford, Coventry, has been charged with conspiracy to traffic within the UK for the purposes of sexual exploitation. Amir Mahmood, 27, a sign writer from Blackwell Road, Foleshill, Coventry, and milkman Tasveer Hussain, 30, of Canal Road, Foleshill, are also accused of the same offence.
Mechanic Saleem Hussain, 30, from Beake Avenue, Coventry, has been charged with sexual assault, and Khezer Hussain, 25, from Bordesley Green East, Stechford, Birmingham, faces an accusation of rape.
The police spokesman added: “The five alleged victims remain safeguarded and continue to be supported by specially-trained officers from the West Midlands Police’s Public Protection Unit along with partnership agencies including Coventry City Council Children’s Services.”